Author

P. Percipalle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

T. Venit· 5 shared G. Esposito· 2 shared Y. Idaghdour· 2 shared A. dos Santos· 1 shared A. Grosse-Berkenbusch· 1 shared A. Leonchiks· 1 shared A. W. Cook· 1 shared C. Breunig· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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5 shared papersCell Biology

T. Venit

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Assessing nanobody interaction with SARS-CoV-2 Nsp9

G. Esposito, Y. Hunashal, M. Percipalle, F. Fogolari, T. Venit, A. Leonchiks, K. C. Gunsalus, F. Piano, P. Percipalle

This study investigates the interaction between SARS-CoV-2 Nsp9 and nanobody 2NSP90 using NMR spectroscopy and molecular dynamics simulations, revealing stoichiometry and epitope details.

bioRxiv · Oct 20, 2023Biophysics

Nanobodies against SARS-CoV-2 non-structural protein Nsp9 inhibit viral replication by targeting innate immunity

T. Venit, J. Blavier, S. B. Maseko, S. Shu, L. Espada, C. Breunig, H.-P. Holthoff, S. C. Desbordes, M. Lohse, G. Esposito, J.-C. Twizere, P. Percipalle

This paper designs nanobodies against SARS-CoV-2 Nsp9 to inhibit viral replication, showing effectiveness against multiple variants in HEK293-ACE2 cells.

bioRxiv · Oct 12, 2023 · PreprintCell Biology

Nuclear Myosin 1 regulates platelet activation and immune response: A novel therapeutic target for hematologic disorders

T. Venit, S. Khalaji, V. Fambri, W. Abdrobou, M. El Gindi, R. Shrestha, P. Hozak, Y. Idaghdour, J. Teo, P. Percipalle

This study shows that Nuclear Myosin 1 (NM1) regulates hematopoiesis and immune response, with NM1 deletion causing metabolic shifts and impaired blood cell function, suggesting NM1 as a therapeutic target for hematologic disorders.

bioRxiv · Feb 14, 2023 · PreprintCell Biology

Regulation of oxidative phosphorylation by Nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice

T. Venit, O. Sapkota, W. S. Abdrabou, P. Loganathan, R. Pasricha, S. R. Mahmood, N. El Said, S. Thomas, Y. Idaghdour, M. Magzoub, P. Percipalle

This study shows that nuclear myosin 1 regulates oxidative phosphorylation and prevents metabolic reprogramming and tumorigenesis in mice by modulating mitochondrial function and the PI3K/Akt/mTOR pathway.

bioRxiv · Jun 30, 2022 · PreprintCell Biology

Nuclear myosin VI regulates the spatial organization of mammalian transcription initiation.

Y. Hari-Gupta, N. Fili, A. dos Santos, A. W. Cook, R. E. Gough, H. C. W. Reed, L. Wang, J. Arron, T. Venit, E. Waite, A. Grosse-Berkenbusch, J. C. M. Gebhardt, P. Percipalle, T. L. Chew, M. L. Martin-Fernandez, C. P. Toseland

This study identifies nuclear myosin VI as a molecular anchor for RNA Polymerase II clusters, showing its role in maintaining transcription factory organization and gene expression.

bioRxiv · Apr 21, 2020Cell Biology