N. Jia

Structural basis for ssDNA-activated NADase activity of the prokaryotic SPARTA immune system

The paper determines the structure of the SPARTA immune system, revealing how it activates NADase activity in response to ssDNA targets.

A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation

This study identifies RME-8/DNAJC13 as a conserved factor required for autolysosome reformation in neurons, linking it to autophagic flux and neurodegenerative disease mechanisms.

Structural rearrangements of a caspase-like protease TPR-CHAT govern virus-host discrimination during type III-E CRISPR-Caspase immunity

The paper reports cryo-EM structures of gRAMP-crRNA and gRAMP-crRNA-TPR-CHAT complexes, revealing how TPR-CHAT discriminates between self and non-self RNA targets through conformational changes.

SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors

This study identifies multiple innate immune receptors that recognize SARS-CoV-2 spike protein through glycan-dependent interactions, suggesting potential therapeutic targets.

Resident and elicited macrophages differ in expression of their glycomes and lectins

The paper compares glycome and lectin gene expression between resident and elicited macrophages, finding differences in glycan types and lectin gene expression.