Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis
David R. Ziehr, Fei Li, K. Mark Parnell, Nathan M. Krah, Kevin J. Leahy, Christelle Guillermier, Ce Gao, Sean A. Prell, Niv Vigder, Sergio Poli, Jack Varon, Rebecca M. Baron, Bradley A. Maron, Nancy J. Philp, Lida P. Hariri, , William M. Oldham
The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.
Science Translational Medicine · May 1, 2022Peer-reviewedCell Biology