Author

Kevin J. Leahy

Brigham and Women's HospitalORCID 0009-0001-3552-1899Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

William M. OldhamiD· 2 shared Adam Skepner· 1 shared Bai ZheniD· 1 shared Bradley A. MaroniD· 1 shared Ce GaoiD· 1 shared Christelle GuillermieriD· 1 shared David R. ZiehriD· 1 shared Edy Y. KimiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioinformatics

William M. OldhamORCID

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2 papers

Recent·Most cited

ExplainBind: Explainable Physicochemical Determinants of Protein-Ligand Binding via Non-Covalent Interactions

Zhaohan Meng, Bai Zhen, Ke Yuan, Jiangning Song, Yumeng Zhang, Jaime H. Cheah, Wei Jiang, Adam Skepner, Kevin J. Leahy, Iadh Ounis, William M. Oldham, Zaiqiao Meng, Hao Xu, Joseph Loscalzo

ExplainBind predicts protein-ligand binding likelihood and identifies key residues and non-covalent interactions without structural inputs, outperforming existing methods and enabling drug discovery insights.

bioRxiv · Jun 9, 2026 · PreprintBioinformatics

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis

David R. Ziehr, Fei Li, K. Mark Parnell, Nathan M. Krah, Kevin J. Leahy, Christelle Guillermier, Ce Gao, Sean A. Prell, Niv Vigder, Sergio Poli, Jack Varon, Rebecca M. Baron, Bradley A. Maron, Nancy J. Philp, Lida P. Hariri, , William M. Oldham

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

Science Translational Medicine · May 1, 2022Peer-reviewedCell Biology