A structure-guided pipeline yields peptide inhibitors that disarm fungal peptidase-driven virulence and resistance
Davier Gutierrez‐Gongora, Jacob Hambly, Norris Chan, Oscar Romero, Michael Woods, Esther Olabisi-Adeniyi, Aimee Maria Dawe, María Juliana Mantilla, Gregory A. Wasney, Jared S. Deyarmin, Stephanie N. Samra, Pedro Alberto Valiente, Melanie Alpaugh, Adnane Sellam, Ryan S. Prosser, , Jennifer Geddes‐McAlister
The paper designs peptide inhibitors targeting fungal peptidases to reduce virulence and resistance without harming host cells, showing efficacy in vitro and in vivo.
bioRxiv · Apr 10, 2026 · PreprintMicrobiology