Norris Chan

Systematic Infectome-Phenome Profiling Reveals Cryptococcal Infection-Associated Proteins Driving Immune System Remodeling and Immunization Potential

This study identifies fungal proteins involved in immune system remodeling and immunization potential using a combined proteomics and phenotyping approach in Cryptococcus neoformans.

Iron-responsive phosphorylation of TolQ modulates cell envelope integrity and antibiotic susceptibility in Klebsiella pneumoniae

This study identifies iron-dependent phosphorylation of TolQ in K. pneumoniae, linking iron availability to Tol-Pal system function and antibiotic susceptibility.

SbmA coordinates iron homeostasis and antimicrobial susceptibility in Klebsiella pneumoniae through phosphorylation-dependent regulation

This study identifies SbmA as a regulator of iron homeostasis and antimicrobial susceptibility in K. pneumoniae through phosphorylation-dependent mechanisms, revealing it as a potential therapeutic target.

A structure-guided pipeline yields peptide inhibitors that disarm fungal peptidase-driven virulence and resistance

The paper designs peptide inhibitors targeting fungal peptidases to reduce virulence and resistance without harming host cells, showing efficacy in vitro and in vivo.

Spatiotemporal dynamics of cryptococcal infection reveal novel immune modulatory mechanisms and antifungal targets

This study uses mass spectrometry to analyze proteome changes in three organs during Cryptococcus neoformans infection, identifying new immune modulatory mechanisms and antifungal targets.