María Juliana Mantilla

This study identifies Isw2-mediated chromatin remodeling as a regulator of antifungal tolerance and heteroresistance in Candida albicans, revealing its role in suppressing CRZ1 transcription and modulating drug responses.

The paper designs peptide inhibitors targeting fungal peptidases to reduce virulence and resistance without harming host cells, showing efficacy in vitro and in vivo.