REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR
Junghyun L. Suh, Daniel Bsteh, Bryce Hart, Yibo Si, Tyler Weaver, Carina Pribitzer, Roy Lau, Shivani Soni, Heather Anne N. Ogana, Justin M. Rectenwald, Jacqueline L. Norris, Stephanie H. Cholensky, Cari A. Sagum, Jessica M. Umana, Dongxu Li, , Oliver Bell
This paper identifies UNC7040 as a potent CBX8-specific positive allosteric modulator that disrupts PRC1 function and reduces cancer cell proliferation.
Cell chemical biology · Oct 28, 2021Peer-reviewedSynthetic Biology