Corticosteroids elevate intraocular pressure through suppression of TREK-1 signaling
Sarah N. Redmon, Oleg V. Yarishkin, Christopher N. Rudzitis, Mónika Lakk, Jacques Bertrand, Joseph M. Sherwood, Christina M. Nicou, Christopher L. Passaglia, Darryl R. Overby, David Križaj
This study shows corticosteroids increase intraocular pressure by suppressing TREK-1 channels in trabecular meshwork cells, leading to ocular hypertension, which can be counteracted by TREK-1 agonists.
bioRxiv · Aug 14, 2025 · PreprintPhysiology