Decoding efficacy and resistance space at a drug binding site
Simone Altmann, César Mendoza-Martínez, Melanie C. Ridgway, Michele Tinti, Jagmohan Saini, Peter E. G. F. Ibrahim, Michael G. Thomas, Manu De Rycker, Michael J. Bodkin, David Horn
The paper uses MOT-library profiling to assess all possible mutations at a drug binding site and predicts resistance mechanisms through computational modeling.
Nature Communications · Feb 4, 2026Peer-reviewedMolecular Biology