Author

Manu De Rycker

University of DundeeORCID 0000-0002-3171-3519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

César Mendoza-MartíneziD· 1 shared David HorniD· 1 shared Jagmohan Saini· 1 shared Juliana da Silva PachecoiD· 1 shared Luciana S. Paradela· 1 shared Marta García-SáncheziD· 1 shared Melanie C. RidgwayiD· 1 shared Michael G. ThomasiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

César Mendoza-MartínezORCID

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2 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedMay 25, 2026

The Trypanosoma cruzi cell atlas; a single-cell resource for understanding parasite population heterogeneity and differentiation.

Ross F. Laidlaw, Marta García-Sánchez, Juliana da Silva Pacheco…·Manu De Rycker

This paper creates a single-cell atlas of Trypanosoma cruzi, revealing life cycle genes, cell heterogeneity, and transcriptomic changes during differentiation.

10 citationstop 1%

scRNA-seqexperimental assay

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Molecular BiologyNature CommunicationsPeer-reviewedFeb 4, 2026

Decoding efficacy and resistance space at a drug binding site

Simone Altmann, César Mendoza-Martínez, Melanie C. Ridgway…·David Horn

The paper uses MOT-library profiling to assess all possible mutations at a drug binding site and predicts resistance mechanisms through computational modeling.

1 citation

experimental assaydrug response / drug discovery

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