PD-1 blockade during T cell priming enhances long-term protection against metastatic tumors by epigenetically tuning T cell exhaustion
Teresa Dinter, Sebastian D. Mackowiak, Zachary J. Rogers, Vidit Bhandarkar, Molly Y. Carney, Yiming J. Zhang, Duncan M. Morgan, Lorelai Pop, Fiona Chatterjee, Emi A. Lutz, Jain Yajit, Adityanarayanan Radhakrishnan, Eric S. Lander, Karl Dane Wittrup, John Christopher Love, , Stefani Spranger
This study shows PD-1 blockade during T cell priming promotes an intermediate-exhausted CD8 T cell state that supports durable anti-tumor immunity after surgery and metastatic challenge, better than effector or memory-like T cells.
bioRxiv · Nov 25, 2025 · PreprintImmunology