Ketone body beta-hydroxybutyrate restores neuronal Tau proteostasis via ketolysis-independent mechanism
Leigh-Ana M. Rossitto, Jamie Foo, Julia M Di Silvestri, Leanne M Lehmann, Melina Brunelli, Yuhang Nie, Daniel Muñoz-Mayorga, Qiang Xiao, Anna Y Dai-Liu, Suborno Jati, Meghan Rossi, Richard Daneman, Jeffery W. Kelly, John C. Newman, Samuel A. Myers, Xu Chen
This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.
bioRxiv · Feb 2, 2026 · PreprintNeuroscience