Melina Brunelli

The paper demonstrates that background proteome correction improves the accuracy of identifying dynamic protein-protein interactions by reducing false positives and negatives in AP-MS experiments.

This study shows that beta-hydroxybutyrate (betaHB) improves neuronal Tau proteostasis and reduces Tau aggregation in tauopathy models, independent of its ketolysis for ATP production.

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.

This study shows that adapting Drosophila to a high-sugar diet increases lifespan and reveals cholinergic signaling's role in longevity under overnutrition.