Author

Vanessa Point

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Stéphane CanaaniD· 5 shared Janïs Laudouze· 4 shared Pierre SantucciiD· 4 shared Céline CrausteiD· 3 shared Wafaa Achache· 3 shared Eliana Sepulveda Ramos· 2 shared Gabriela GagoiD· 2 shared Maria Sofia Deschutter· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersMicrobiology

Stéphane CanaanORCID

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Author profile →

5 papers

Recent·Most cited

Development of inducible genetic systems to finely tune efficacy of InhA-targeting anti-tuberculous drugs

Eliana Sepulveda Ramos, Maria Sofia Deschutter, Vanessa Point, Thibault Brunet, Janïs Laudouze, Wafaa Achache, Céline Crauste, Stéphane Canaan, Gabriela Gago, Mickaël Maziero, Pierre Santucci

This paper develops CRISPRi-based inducible systems to fine-tune antibiotic susceptibility in Mycobacterium tuberculosis by targeting key genes involved in drug activation.

bioRxiv · Oct 7, 2026 · PreprintMicrobiology

Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems

Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci

This paper describes a CRISPRi-based protocol to assess gene silencing and envelope transitions in Mycobacterium smegmatis as a model for NTM pathogenesis.

FEBS Open Bio · Nov 30, 2025Peer-reviewedMicrobiology

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

Janïs Laudouze, Tatyana I. Rokitskaya, Akira Abolet, Vanessa Point, Alexander M. Firsov, Ljudmila S. Khailova, Maria Sofia Deschutter, Gabriela Gago, Jean‐François Cavalier, Stéphane Canaan, Alain R. Baulard, Yuri N. Antonenko, Alexandre Gouzy, Pierre Santucci

This study investigates the mechanism of action of pyrazinamide (PZA) in Mycobacterium tuberculosis, showing it kills bacteria by acidifying cytosol via pH-driven weak-acid permeation, independent of PanD and pantothenate levels.

bioRxiv · Sep 26, 2025 · PreprintMicrobiology

Fluorescence-based CRISPR interference system for controlled genetic repression and live single-cell imaging in mycobacteria

Janïs Laudouze, Vanessa Point, Wafaa Achache, Céline Crauste, Stéphane Canaan, Pierre Santucci

The paper develops and validates fluorescence-based CRISPRi tools for gene repression and live single-cell imaging in mycobacteria.

FEBS Letters · Dec 1, 2024Peer-reviewedMicrobiology

Characterization and rescue by oxytocin of an atypical thermo-sensory reactivity in neonatal mice lacking the autism-associated gene Magel2.

Laura Caccialupi Da Prato, Dina Abdallah, Vanessa Point, Fabienne Schaller, Emilie Pallesi‐Pocachard, Aurélie Montheil, Stéphane Canaan, Jean‐Luc Gaïarsa, Françoise Muscatelli, Valery A. Matarazzo

This study identifies early life thermosensory impairments in Magel2-deficient mice and shows oxytocin treatment can rescue these deficits.

bioRxiv · Feb 11, 2021 · PreprintNeuroscience