Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8+ T cells
Tingyuan Yang, Himani Sharma, Jenna M. Benson, William J. Valente, Rebecca S. LaRue, Beau R. Webber, Branden S. Moriarity, Christopher A. Pennell, Stephen C. Jameson, Ameeta Kelekar
This study identifies Noxa's role in metabolic reprogramming to glutamine dependence in CD8+ T cells, independent of its canonical apoptotic function, and suggests its potential as an immunotherapeutic target.
bioRxiv · Dec 10, 2025 · PreprintImmunology