Exploring the Structural and Functional role of α,β-unsaturated Ketoesters as Anti-Staphylococcal Agents Targeting Glutathione Peroxidase
Sushobhan Maji, Sayoni Dam, Akanksha Kumari, Himani Sharma, Naveen Sharma, Nirmal Kumar Rana, Asmita Samadder, Sudipta Bhattacharyya
This study identifies SaGpx as a virulence factor in S. aureus and develops β-unsaturated ketoester inhibitors that block its activity, showing antibacterial and wound healing effects in vivo.
bioRxiv · Jun 18, 2026 · PreprintBiophysics