Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine
Genaro Hernandez, Adam Osinski, Abir Majumdar, Jennifer L. Eitson, Monika I. Antczak, Krzysztof Pawłowski, Hanspeter Niederstrasser, Kelly A. Servage, Bruce A. Posner, John W. Schoggins, Joseph M. Ready, Vincent S. Tagliabracci
The paper identifies NCI-2, a covalent inhibitor of the SARS-CoV-2 NiRAN domain, and presents a structural blueprint for drug design.
Journal of Biological Chemistry · Mar 4, 2025Peer-reviewedBiochemistry