Krzysztof Pawłowski

YfiM is a lipid-linked oligosaccharide pyrophosphatase

The paper identifies YfiM and AT1G15900 as LLO pyrophosphatases in E. coli and Arabidopsis, revealing a conserved quality control mechanism across prokaryotes and plants.

TIR-like NADases act in bacterial immunity and the RNA vault

This study identifies DUF4062 as TIR-like NADases involved in bacterial antiphage defense and eukaryotic RNA vault function through structural and biochemical analyses.

Bacterial ubiquitin ligase engineered for small molecule and protein target identification

This paper introduces SidBait, a modular proximity ligation approach to identify small molecule and protein targets, validated with known interactions and applied to discover new targets like CaMKII and CapZ.

ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways

This study identifies ACAD10 as encoding two enzymes involved in ether lipid biosynthesis and salvage, linking them to type 2 diabetes risk.

Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine

The paper identifies NCI-2, a covalent inhibitor of the SARS-CoV-2 NiRAN domain, and presents a structural blueprint for drug design.

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

A survey of ADP-ribosyltransferase families in the pathogenic Legionella

The paper identifies 63 ART-like proteins in 41 Legionella species, organized into 39 families, including 26 novel ones, and proposes a database for further study.

Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts

The paper identifies six proteins that predict response to immune checkpoint therapy across three melanoma cohorts and correlate with patient survival.

A novel predicted ADP-ribosyltransferase family conserved in eukaryotic evolution

The paper identifies a novel ADP-ribosyltransferase family conserved across eukaryotes, suggesting a role in innate immune signaling through ADP-ribosylation.