Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation
Janine L. Gray, Elizabeth V. K. Ledger, Tiffany Suwatthee, Thomas J. Burden, Konstantina Arvaniti, Amber Y. Sefton, Lydia E. Papagora, Thomas B. Clarke, Jennifer Riley, Érika G. Pinto, Fraser Cunningham, Ian Hugh Gilbert, David W. Gray, Da‐Neng Wang, Kevin D. Read, , Edward W. Tate
The paper identifies IMP-2380, a potent NorA inhibitor that enhances antibiotic activity by stabilizing the outward-open conformation of the efflux pump.
bioRxiv · Aug 19, 2025 · PreprintBiochemistry