Author

Thomas B. Clarke

Imperial College LondonORCID 0000-0002-9997-9532Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1

Frequent Co-Authors

Alexander YipiD· 1 shared Amber Y. Sefton· 1 shared Andrew M. EdwardsiD· 1 shared Benjamin Harvey MullishiD· 1 shared Da‐Neng WangiD· 1 shared David W. GrayiD· 1 shared Edward W. TateiD· 1 shared Elizabeth V. K. LedgeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

Alexander YipORCID

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2 papers

Recent·Most cited

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation

Janine L. Gray, Elizabeth V. K. Ledger, Tiffany Suwatthee, Thomas J. Burden, Konstantina Arvaniti, Amber Y. Sefton, Lydia E. Papagora, Thomas B. Clarke, Jennifer Riley, Érika G. Pinto, Fraser Cunningham, Ian Hugh Gilbert, David W. Gray, Da‐Neng Wang, Kevin D. Read, , Edward W. Tate

The paper identifies IMP-2380, a potent NorA inhibitor that enhances antibiotic activity by stabilizing the outward-open conformation of the efflux pump.

bioRxiv · Aug 19, 2025 · PreprintBiochemistry

Vancomycin-resistant enterococci colonise the antibiotic-treated intestine by occupying overlapping but distinct nutrient- and metabolite-defined intestinal niches

Olivia G. King, Alexander Yip, Victoria Horrocks, Jesús Miguéns Blanco, Julian Roberto Marchesi, Benjamin Harvey Mullish, Thomas B. Clarke, Julie A. K. McDonald

This study shows that VRE colonize the antibiotic-treated intestine by occupying distinct nutrient-defined niches, using specific nutrients and resisting inhibitory metabolites.

Nature Communications · Jul 10, 2025Peer-reviewedMicrobiology