Author

Jenny D Roe

Virginia Commonwealth University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Claire D. JamesiD· 4 shared Iain M. MorganiD· 4 shared Molly L. BristoliD· 4 shared Apurva Tadimari PrabhakariD· 3 shared Phoebe V. Bridy· 3 shared Xu Wang· 3 shared Austin J. Witt· 2 shared Austin Witt· 2 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

Claire D. JamesORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles

Apurva Tadimari Prabhakar, Claire D. James, A. Nguyen, Phoebe V. Bridy, Xu Wang, Ryan J. Zoldork, Jenny D Roe, Austin J. Witt, Srimanya S. Panidepu, Sarita Giri, Molly L. Bristol, Krista Dalton, Andreas Wieland, Ahmed Diab, Anthony C. Faber, , Iain M. Morgan

This paper shows E2 activates the DNA damage response by displacing CIP2A from TOPBP1, promoting viral replication and cell proliferation through ATM activation and ATR inhibition.

Cell Reports · Oct 26, 2026Peer-reviewedCancer Biology

HPV16 recruitment of SMARCAL1 to viral and host replication forks is required for the viral life cycle

Claire D. James, Aya H. Youssef, Jenny D Roe, Floriana Cappiello, Francesca Antonella Aiello, Benedetta Perdichizzi, Rachel L. Lewis, Austin Witt, Apurva Tadimari Prabhakar, Xu Wang, Molly L. Bristol, Pietro Pichierri, Iain M. Morgan

This paper shows that HPV16 requires SMARCAL1 to recruit to viral and host replication forks, which is essential for its life cycle and prevents DNA damage and genome integration.

mBio · Mar 30, 2026Peer-reviewedMicrobiology

The Utility of Fibroblast Co-culture for the Maintenance of Episomes in Human Papillomavirus-Associated Cancer Models

Austin J. Witt, Rachel L. Lewis, Xu Wang, Phoebe V. Bridy, Jenny D Roe, Iain M. Morgan, Claire D. James, Molly L. Bristol

The paper shows that HPV16+ OPC cell lines lose episomal status in monoculture and proposes fibroblast co-culture to maintain episomal viral genomes.

mSphere · Feb 25, 2026Peer-reviewedCancer Biology

Differentiation-Dependent Proximity Proteomics Identifies Novel Host Factors Linked to HPV16 E2 Function

Claire D. James, Aya H. Youssef, Apurva Tadimari Prabhakar, Jenny D Roe, Elinor Lu, Austin Witt, Sarita Giri, Molly L. Bristol, Phoebe V. Bridy, Xu Wang, Arjun Rijal, Charles E. Lyons, Iain M. Morgan

This study identifies novel host factors interacting with HPV16 E2 during differentiation using proximity proteomics, revealing a cooperative E2-TOPBP1-NCL axis critical for viral genome stability.

mBio · Jan 12, 2026Peer-reviewedCancer Biology