Discovery of Small Molecules and a Druggable Groove That Regulate DNA Binding and Release of the AP1 Transcription Factor DeltaFOSB
Sean McNeme, Yun Young Yim, Ashwani Kumar, Yi Li, Brandon W. Hughes, Corey P. St. Romain, Galina V. Aglyamova, Jianping Chen, Nghi D. Nguyen, Shanghua Fan, Gabriel S. Stephens, Wen‐Ning Zhao, Samantha J. Kruzshak, Molly S. Estill, Corrine Brener, , Gabby Rudenko
The paper identifies a druggable groove on DeltaFOSB that allows small molecules to modulate its DNA binding and release, with one compound reducing genomic occupancy by 60% in vivo.
Journal of Biological Chemistry · Dec 22, 2025Peer-reviewedNeuroscience