Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons
Max Koppers, Roberta Cagnetta, Toshiaki Shigeoka, Lucia C. S. Wunderlich, Pedro P. Vallejo Ramirez, Julie Qiaojin Lin, Sixian Zhao, Maximilian AH Jakobs, Asha Dwivedy, Michael S. Minett, Anaïs Bellon, Clemens F. Kaminski, William A. Harris, John G Flanagan, Christine E. Holt
The paper shows that receptor-ribosome coupling enables selective mRNA translation in axons in response to guidance cues, with receptor-specific interactomes mediating this process.
eLife · Nov 20, 2019Peer-reviewedDevelopmental Biology