On-site ribosome remodeling by locally synthesized ribosomal proteins in axons
Toshiaki Shigeoka, Max Koppers, Hovy Ho‐Wai Wong, Julie Qiaojin Lin, Roberta Cagnetta, Asha Dwivedy, Janaina De Freitas Nascimento, Francesca W. van Tartwijk, Florian Ströhl, Jean-Michel Cioni, Julia Schaeffer, Mark Carrington, Clemens F. Kaminski, Hosung Jung, William A. Harris, Christine E. Holt
The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.
Cell Reports · Dec 1, 2019Peer-reviewedNeuroscience