Author

Maximilian AH Jakobs

University of CambridgeORCID 0000-0002-0879-7937Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1

Frequent Co-Authors

Christine E. HoltiD· 2 shared Clemens F. KaminskiiD· 2 shared Julie Qiaojin LiniD· 2 shared Lucia C. S. WunderlichiD· 2 shared Anaïs BelloniD· 1 shared Asha Dwivedy· 1 shared Daniel St JohnstoniD· 1 shared Dmitry NashchekiniD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Christine E. HoltORCID

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3 papers

Recent·Most cited

Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

Francesca W. van Tartwijk, Lucia C. S. Wunderlich, Ioanna Mela, Stanislaw Makarchuk, Maximilian AH Jakobs, Seema Qamar, Kristian Franze, Gabriele S. Kaminski Schierle, Peter St George‐Hyslop, Julie Qiaojin Lin, Christine E. Holt, Clemens F. Kaminski

The paper investigates how mutations in the FUS protein affect axonal cytoskeletal organisation in ALS/FTD models, finding reduced actin density and axonal branch complexity.

Journal of Neuroscience · May 1, 2024Peer-reviewedNeuroscience

Symmetry breaking in the female germline cyst

Dmitry Nashchekin, Lara C. Busby, Maximilian AH Jakobs, Iolo J. Squires, Daniel St Johnston

The paper identifies a molecular mechanism by which Patronin amplifies fusome asymmetry to select the oocyte in the female germline cyst.

Science · Nov 11, 2021Peer-reviewedDevelopmental Biology

Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

Max Koppers, Roberta Cagnetta, Toshiaki Shigeoka, Lucia C. S. Wunderlich, Pedro P. Vallejo Ramirez, Julie Qiaojin Lin, Sixian Zhao, Maximilian AH Jakobs, Asha Dwivedy, Michael S. Minett, Anaïs Bellon, Clemens F. Kaminski, William A. Harris, John G Flanagan, Christine E. Holt

The paper shows that receptor-ribosome coupling enables selective mRNA translation in axons in response to guidance cues, with receptor-specific interactomes mediating this process.

eLife · Nov 20, 2019Peer-reviewedDevelopmental Biology