Christine E. Holt

Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

The paper investigates how mutations in the FUS protein affect axonal cytoskeletal organisation in ALS/FTD models, finding reduced actin density and axonal branch complexity.

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.

Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

The paper shows that receptor-ribosome coupling enables selective mRNA translation in axons in response to guidance cues, with receptor-specific interactomes mediating this process.

Simultaneous in vivo time-lapse stiffness mapping and fluorescence imaging of developing tissue

This study uses tiv-AFM to show that in vivo tissue stiffness gradients in Xenopus brain development are driven by differential cell proliferation and guide axon growth.