Julie Qiaojin Lin

Multiscale transcriptomic organization of the human brain with DigitalBrain

DigitalBrain integrates and organizes human brain transcriptomic data across scales, revealing hierarchical organization and age-related gene reorganization.

RNA secondary structures modulate hnRNPH1-mediated alternative splicing of cold-shock protein RBM3

This study identifies RNA G-quadruplex remodelling as the key mechanism by which temperature modulates hnRNPH1-mediated alternative splicing of RBM3.

In Situ Integration of Porous Polyethylene Nanomembrane with Wound Exudates for Scarless Healing

This study introduces pgPE, a porous polyethylene nanomembrane that absorbs wound exudates to promote scarless healing by modulating immune responses and alleviating hypoxia.

Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

The paper investigates how mutations in the FUS protein affect axonal cytoskeletal organisation in ALS/FTD models, finding reduced actin density and axonal branch complexity.

HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion

This study identifies HNRNPH1 as a key regulator of RBM3 expression through cold-induced exon skipping, offering potential therapeutic targets for neuroprotection.

A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view

This paper introduces a waveguide-based TIRFM system for live-cell imaging of delicate neurons over large fields of view, demonstrating its use with fibroblasts, rat hippocampal neurons, and Xenopus retinal ganglion cells.

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

The paper shows that ribosomal proteins are synthesized locally in axons and incorporated into ribosomes in a nucleolus-independent manner, regulated by a novel RNA motif.

Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

The paper shows that receptor-ribosome coupling enables selective mRNA translation in axons in response to guidance cues, with receptor-specific interactomes mediating this process.