Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice
Joan Cruz-Sesé, Marta Miron-Alcala, María Alfonso-Triguero, Jon Olalde, Leire Ruiz, Nuria Galbis-Gramage, Lorea Cortes, Laura Escobar, Pranav Preman, An Snellinx, Takashi Saito, Takaomi C. Saido, Laura Saiz-Aúz, Alberto Rábano‐Gutierrez, Julia TCW, , Amaia M. Arranz
This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.
bioRxiv · Jan 28, 2025 · PreprintNeuroscience