This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.

bioRxiv · Jan 28, 2025 · PreprintNeuroscience

A multi-pronged human microglia response to Alzheimer's disease Aβ pathology

Renzo Mancuso, Nicola Fattorelli, Anna Martínez‐Muriana, Emma Davis, Leen Wolfs, Johanna Van Den Daele, Ivana Geric, Jessie Premereur, Paula Polanco Miquel, Baukje Bijnens, Pranav Preman, Lutgarde Serneels, Suresh Kumar Poovathingal, Sriram Balusu, Catherine M. Verfaillie, , Bart De Strooper

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

Nature Neuroscience · Mar 27, 2024Peer-reviewedNeuroscience

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's Disease

Disha Shah, Willy Gsell, Jérôme Wahis, Emma Susanne Luckett, Tarik Jamoulle, Ben Vermaercke, Pranav Preman, Daan Moechars, Véronique Hendrickx, Tom Jaspers, Katleen Craessaerts, Katrien Horré, Leen Wolfs, Mark W. E. J. Fiers, Matthew G. Holt, , Bart De Strooper

The paper shows that astrocyte calcium dysfunction leads to early network hyperactivity in Alzheimer's Disease, which can be reversed by restoring calcium signaling.

Cell Reports · Aug 1, 2022Peer-reviewedNeuroscience

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaques

Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, María Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart De Strooper, Amaia M. Arranz

The paper transplants human iPSC-derived astrocytes into mouse brains to study their response to amyloid-β plaques, finding morphological changes independent of APOE alleles.

Molecular Neurodegeneration · Sep 25, 2021Peer-reviewedNeuroscience