Author

María Alfonso-Triguero

Achucarro Basque Center for NeuroscienceORCID 0000-0002-5213-0259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:protein structure· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Alison GoateiD· 2 shared Amaia M. ArranziD· 2 shared An Snellinx· 2 shared Bart De StrooperiD· 2 shared Julia TCWiD· 2 shared Pranav PremaniD· 2 shared Alberto Rábano‐Gutierrez· 1 shared Dietmar Rudolf ThaliD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

Alison GoateORCID

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2 papers

Recent·Most cited

Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice

Joan Cruz-Sesé, Marta Miron-Alcala, María Alfonso-Triguero, Jon Olalde, Leire Ruiz, Nuria Galbis-Gramage, Lorea Cortes, Laura Escobar, Pranav Preman, An Snellinx, Takashi Saito, Takaomi C. Saido, Laura Saiz-Aúz, Alberto Rábano‐Gutierrez, Julia TCW, , Amaia M. Arranz

This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.

bioRxiv · Jan 28, 2025 · PreprintNeuroscience

Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-β plaques

Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, María Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison Goate, Bart De Strooper, Amaia M. Arranz

The paper transplants human iPSC-derived astrocytes into mouse brains to study their response to amyloid-β plaques, finding morphological changes independent of APOE alleles.

Molecular Neurodegeneration · Sep 25, 2021Peer-reviewedNeuroscience