Author

Jonathan D. Blumenthal

National Institutes of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 7 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:statistical model· 8 Assay:imaging· 6 Research Focus:differential expression· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:matrix factorization· 2

Frequent Co-Authors

Armin RaznahaniD· 8 shared LIV S. CLASEN· 8 shared François M. LalondeiD· 7 shared Ajay NadigiD· 5 shared Jakob SeidlitziD· 5 shared Jason P. LerchiD· 5 shared Siyuan LiuiD· 5 shared Cassidy L. McDermottiD· 4 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersNeuroscience

Armin RaznahanORCID

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Author profile →

8 papers

Recent·Most cited

A cross-species study of sex chromosome dosage effects on mammalian brain anatomy

Elisa Guma, Antoine Beauchamp, Siyuan Liu, Elizabeth Levitis, LIV S. CLASEN, Erin N. Torres, Jonathan D. Blumenthal, François M. Lalonde, Lily R. Qiu, Haley Hrncir, Allan J. MacKenzie‐Graham, Xia Yang, Arthur P. Arnold, Jason P. Lerch, Armin Raznahan

This study compares the effects of sex chromosome trisomies on brain anatomy in humans and mice, finding species-specific patterns and some conserved regional impacts.

bioRxiv · Aug 30, 2022 · PreprintNeuroscience

Resting-state functional connectivity and psychopathology in Klinefelter syndrome (47, XXY)

Ethan T. Whitman, Siyuan Liu, Erin N. Torres, Allysa Warling, Kathleen E. Wilson, Ajay Nadig, Cassidy L. McDermott, LIV S. CLASEN, Jonathan D. Blumenthal, François M. Lalonde, Stephen J. Gotts, Alex D. Martin, Armin Raznahan

This study maps resting-state functional connectivity changes in Klinefelter syndrome and links them to brain anatomy and psychopathology.

Cerebral Cortex · Mar 16, 2021Peer-reviewedNeuroscience

Transcriptomic and Cellular Decoding of Regional Brain Vulnerability to Neurodevelopmental Disorders

Jakob Seidlitz, Ajay Nadig, Siyuan Liu, Richard A. I. Bethlehem, Petra E. Vértes, Sarah Elizabeth Morgan, František Váša, Rafael Romero-García, François M. Lalonde, LIV S. CLASEN, Jonathan D. Blumenthal, Casey Paquola, Boris C. Bernhardt, Konrad Wagstyl, Damon Polioudakis, , Armin Raznahan

The paper links genetic risks to spatial brain vulnerabilities in neurodevelopmental disorders using neuroimaging and gene expression data.

bioRxiv · Nov 17, 2019 · PreprintNeuroscience

Sex-Biased Trajectories of Amygdalo-Hippocampal Morphology Change Over Human Development

Ari M. Fish, Ajay Nadig, Jakob Seidlitz, Paul Kirkpatrick Reardon, Catherine Mankiw, Cassidy L. McDermott, Jonathan D. Blumenthal, LIV S. CLASEN, François M. Lalonde, Jason P. Lerch, M. Mallar Chakravarty, Russell Taki Shinohara, Armin Raznahan

The paper analyzes longitudinal MRI data to identify sex-biased growth trajectories of the amygdala and hippocampus across human development, revealing differences in volume expansion and shape changes between males and females.

NeuroImage · Aug 27, 2019Peer-reviewedNeuroscience

Longitudinally Mapping Childhood Socioeconomic Status Associations with Cortical and Subcortical Morphology

Cassidy L. McDermott, Jakob Seidlitz, Ajay Nadig, Siyuan Liu, LIV S. CLASEN, Jonathan D. Blumenthal, Paul Kirkpatrick Reardon, François Lalonde, DEANNA K. GREENSTEIN, Raihaan Patel, M. Mallar Chakravarty, Jason P. Lerch, Armin Raznahan

This study examines how childhood socioeconomic status relates to brain morphology changes from age 5 to 25, finding consistent positive associations with brain volume and specific cortical and subcortical regions.

Journal of Neuroscience · Dec 26, 2018Peer-reviewedNeuroscience

Carriage of Supernumerary Sex Chromosomes Decreases the Volume and Alters the Shape of Limbic Structures.

Ajay Nadig, Paul Kirkpatrick Reardon, Jakob Seidlitz, Cassidy L. McDermott, Jonathan D. Blumenthal, LIV S. CLASEN, François M. Lalonde, Jason P. Lerch, M. Mallar Chakravarty, Armin Raznahan

This study examines how supernumerary sex chromosomes affect limbic structure volume and shape in patients compared to controls, finding reduced amygdala volume but no hippocampal volume changes after brain size correction.

eNeuro · Sep 1, 2018Peer-reviewedNeuroscience

Sex Chromosome Dosage Effects On Gene Expression In Humans

Armin Raznahan, Neelroop Parikshak, V. Ravi Chandran, Jonathan D. Blumenthal, LIV S. CLASEN, Aaron F. Alexander‐Bloch, Andrew R. Zinn, Danny Wangsa, Jasen Lee Wise, Declan Murphy, Patrick Bolton, Thomas Ried, JUDITH LEVINE ROSS, Jay N. Giedd, Daniel H. Geschwind

The paper investigates how sex chromosome dosage affects gene expression in humans by analyzing diverse aneuploidies and identifies SCD-sensitive genes and their regulatory networks.

Proceedings of the National Academy of Sciences · Jun 26, 2018Peer-reviewedGenomics

Normative Brain Size Variation and the Remodeling of Brain Shape in Humans

Paul Kirkpatrick Reardon, Jakob Seidlitz, Simon Vandekar, Siyuan Liu, Raihaan Patel, Min Tae M Park, Aaron F. Alexander‐Bloch, LIV S. CLASEN, Jonathan D. Blumenthal, Francois M. Lalonde, Jay N. Giedd, Ruben C. Gur, Raquel E. Gur, Jason P. Lerch, M. Mallar Chakravarty, , Armin Raznahan

The paper finds that larger-brained humans show preferential expansion of fronto-parietal cortical networks and related subcortical regions, at the expense of primary sensory/motor systems.

Science · May 31, 2018Peer-reviewedNeuroscience