François M. Lalonde

dGAMLSS: An exact, distributed algorithm to fit Generalized Additive Models for Location, Scale, and Shape for privacy-preserving population reference charts

The paper introduces dGAMLSS, a distributed algorithm for fitting GAMLSS models to construct population reference charts without sharing patient data.

Fractionation of sex differences in human cortical anatomy

The paper quantifies sex differences in human cortical volume by separating contributions from surface area and thickness, and links these to genetic and hormonal factors using neuroimaging data.

Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia

This study identifies two ASD subgroups with distinct brain morphology using cross-cultural datasets, highlighting key brain regions associated with subgroup characteristics and autistic traits.

The variegation of human brain vulnerability to rare genetic disorders and convergence with behaviorally defined disorders

The paper examines how different gene dosage disorders affect the human brain using multimodal neuroimaging, revealing diverse cortical changes and a shared vulnerability axis aligned with psychiatric disorders.

A cross-species study of sex chromosome dosage effects on mammalian brain anatomy

This study compares the effects of sex chromosome trisomies on brain anatomy in humans and mice, finding species-specific patterns and some conserved regional impacts.

Brain charts for the human lifespan

The paper introduces brain charts as a standardized resource for benchmarking brain morphology across the human lifespan using MRI data from a large and diverse cohort.

Resting-state functional connectivity and psychopathology in Klinefelter syndrome (47, XXY)

This study maps resting-state functional connectivity changes in Klinefelter syndrome and links them to brain anatomy and psychopathology.

Transcriptomic and Cellular Decoding of Regional Brain Vulnerability to Neurodevelopmental Disorders

The paper links genetic risks to spatial brain vulnerabilities in neurodevelopmental disorders using neuroimaging and gene expression data.

In vivo epigenetic editing of sema6a promoter reverses impaired transcallosal connectivity caused by C11orf46/ARL14EP neurodevelopmental risk gene

The paper shows that epigenetic editing of the Sema6a promoter can reverse impaired transcallosal connectivity caused by C11orf46 mutations.

Sex-Biased Trajectories of Amygdalo-Hippocampal Morphology Change Over Human Development

The paper analyzes longitudinal MRI data to identify sex-biased growth trajectories of the amygdala and hippocampus across human development, revealing differences in volume expansion and shape changes between males and females.

Longitudinally Mapping Childhood Socioeconomic Status Associations with Cortical and Subcortical Morphology

This study examines how childhood socioeconomic status relates to brain morphology changes from age 5 to 25, finding consistent positive associations with brain volume and specific cortical and subcortical regions.

Carriage of Supernumerary Sex Chromosomes Decreases the Volume and Alters the Shape of Limbic Structures.

This study examines how supernumerary sex chromosomes affect limbic structure volume and shape in patients compared to controls, finding reduced amygdala volume but no hippocampal volume changes after brain size correction.

Normative Brain Size Variation and the Remodeling of Brain Shape in Humans

The paper finds that larger-brained humans show preferential expansion of fronto-parietal cortical networks and related subcortical regions, at the expense of primary sensory/motor systems.