Lily R. Qiu

Diffusion MRS tracks distinct trajectories of neuronal development in the cerebellum and thalamus of rat neonates.

This study uses diffusion-weighted MRS to track cell-specific developmental trajectories in the cerebellum and thalamus of rat neonates, revealing age-related changes in metabolite diffusion properties.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain

The paper identifies a brain-wide twisting asymmetry in mice, similar to human cerebral petalia, using data from 3,500 animals across six cohorts.

A cross-species study of sex chromosome dosage effects on mammalian brain anatomy

This study compares the effects of sex chromosome trisomies on brain anatomy in humans and mice, finding species-specific patterns and some conserved regional impacts.

Mouse models of immune dysfunction: Their neuroanatomical differences reflect their anxiety-behavioural phenotype

The paper uses MRI and Bayesian hierarchical modeling to show that immune dysfunction in mice affects specific brain regions and correlates with anxiety-like behaviors.

Developmental and behavioral phenotypes in a new mouse model of DDX3X syndrome

This study develops a Ddx3x haploinsufficient mouse model to investigate DDX3X syndrome, finding developmental and behavioral abnormalities linked to brain structural changes.

Neuroanatomy and Behaviour in Mice with a Haploinsufficiency of AT-Rich Interactive Domain 1B (ARID1B) Throughout Development

This study investigates the effects of Arid1b haploinsufficiency in mice, revealing sex-dependent neuroanatomical and behavioral phenotypes associated with neurodevelopmental disorders.

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.

Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring

This study shows that maternal high-fat diet exposure leads to persistent brain changes in adult offspring, affecting regions linked to neurodevelopmental disorders.

Atrx deletion in neurons leads to sexually-dimorphic dysregulation of miR-137 and spatial learning and memory deficits

This study shows that deleting Atrx in mouse forebrain neurons causes male-specific spatial memory deficits linked to miR-137 dysregulation and synaptic abnormalities.

Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus

The paper identifies ASPHD1 as a key driver of reproductive traits in the 16p11.2 locus using biobank data, Mendelian randomization, and animal models.

Genetic and behavioural requirements for structural brain plasticity

The paper investigates how environmental enrichment affects brain volume in mice and identifies molecular processes involved, showing CREB is not required for these changes.

Mouse MRI shows brain areas larger in males emerge earlier than those larger in females

The paper uses MRI to show male-specific brain areas develop earlier than female-specific ones in mice across postnatal development.