Author

Jason Xu

University of LouisvilleORCID 0000-0002-9061-3593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Kai TaniD· 2 shared Vinodh PillaiiD· 2 shared Adam BaggiD· 1 shared Adam Barsouk· 1 shared Alain H. RookiD· 1 shared Alberto CarturaniD· 1 shared Andrew Evan Lee· 1 shared Antonia RotoloiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Kai TanORCID

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3 papers

Recent·Most cited

Distinct and shared synergistic effects of high-fat and high-iron diets on liver tumorigenesis and transcriptomic remodeling in mice

Debodipta Das, Hakim Bouamar, Xiaoli Sun, Jason Xu, Lu Cai, Yidong Chen, Francis E. Sharkey, Sukeshi Patel Arora, Francisco G. Cigarroa, Lu‐Zhe Sun

This study examines how high-fat and high-iron diets affect liver tumorigenesis and transcriptomic changes in mice, finding shared and distinct molecular effects.

bioRxiv · May 27, 2026 · PreprintCancer Biology

Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T cell therapies

Alberto Carturan, Mathew G. Angelos, Puneeth Guruprasad, Ruchi P. Patel, Raymone Pajarillo, Andrew Evan Lee, Yunlin Zhang, Wei Xie, Jesse L. Rodriguez, Jaryse Harris, Pooja Devi, Olabisi I. Afolayan-Oloye, Jason Xu, Jonathan H. Sussman, Omar Elghawy, , Marco Ruella

This paper develops anti-CD2 CAR T-cells that overcome fratricide and improve efficacy by incorporating a PD-1:CD2 switch receptor to restore CD2 signaling.

Blood · Jan 5, 2026Peer-reviewedCancer Biology

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

Shovik Bandyopadhyay, Michael Duffy, Kyung Jin Ahn, Minxing Pang, David Smith, Gwendolyn Duncan, Jonathan Sussman, Iris Zhang, Jeffrey Huang, Yulieh Lin, Barbara Xiong, Tamjid Imtiaz, Chia-Hui Chen, Anusha Thadi, Changya Chen, , Kai Tan

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

bioRxiv · Mar 14, 2024 · PreprintCell Biology