Author

Yazhini Thinakaran

Brock University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Evangelia TsianiiD· 2 shared Mahdi Hejazi Laein· 2 shared Maryam Katoueezadeh· 2 shared Neil E. McCarthyiD· 2 shared Panagiota KlentrouiD· 2 shared Pazhanichamy KalailingamiD· 2 shared Ranjith IyappaniD· 2 shared Rebecca E. K. MacPhersoniD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Evangelia TsianiORCID

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2 papers

Recent·Most cited

Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic Pancreatic Cancer Model

Maryam Katoueezadeh, Yazhini Thinakaran, Mahdi Hejazi Laein, Ranjith Iyappan, SoFong Cam Ngan, Jake Baker, Ridhi Patel, Pazhanichamy Kalailingam, Rebecca E. K. MacPherson, Panagiota Klentrou, Evangelia Tsiani, Jee Keem Low, Neil E. McCarthy, Siu Kwan Sze

This study shows that inducing oxidative stress in pancreatic cancer cells creates an effective whole-cell vaccine that enhances anti-tumor immunity and synergizes with PD-1 blockade.

bioRxiv · Feb 11, 2026 · PreprintCancer Biology

IsoDGR-Induced Endothelial Cytoskeletal Disruption Drives Age-Related Blood-Brain Barrier Breakdown

Ridhi Patel, Pazhanichamy Kalailingam, SoFong Cam Ngan, Ranjith Iyappan, Jones Nwaeze, Bianca D’Amore, Maryam Katoueezadeh, Yazhini Thinakaran, Mahdi Hejazi Laein, Brent E. Faught, Rebecca E. K. MacPherson, Evangelia Tsiani, Panagiota Klentrou, Dominique P.V. de Kleijn, Raj N. Kalaria, , Siu Kwan Sze

This study identifies isoDGR-induced endothelial cytoskeletal disruption as a key driver of age-related BBB breakdown and shows that targeting isoDGR preserves BBB integrity and reduces neuroinflammation.

bioRxiv · Jul 8, 2025 · PreprintNeuroscience