Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic spine maturation
Ben Verpoort, Luísa Amado, Jeroen Vandensteen, Elke Leysen, Dan Dascenco, Joris Vandenbempt, Irma H. Lemmens, Joris Wauman, Kristel M. Vennekens, Abril Escamilla‐Ayala, Ana Cristina Nogueira Freitas, Thomas Voets, Sebastian Munck, Jan H. Tavernier, Keimpe D. B. Wierda, Joris de Wit
This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.
Developmental Cell · May 19, 2025Peer-reviewedNeuroscience