Jan H. Tavernier

Cell-surface receptor-mediated regulation of synaptic organelle distribution controls dendritic spine maturation

This study identifies a postsynaptic signaling complex involving GPR158 and PLCXD2 that regulates synaptic organelle distribution and dendritic spine maturation through modulation of the lipid microenvironment.

Crosstalk interactions between transcription factors ERRalpha and PPARalpha assist PPARalpha-mediated gene expression

The paper identifies crosstalk between ERRalpha and PPARalpha transcription factors, showing ERRalpha can act as both a repressor and activator of PPARalpha-mediated gene expression.

Mechanism of receptor assembly via the pleiotropic adipokine Leptin

This study reveals the structure and mechanism of Leptin-mediated LEP-R assembly, showing a 3:3 stoichiometry and highlighting the role of Leptin restructuring in activating signaling.

Maximizing binary interactome mapping with a minimal number of assays

The paper introduces an assayome concept to optimize binary interactome mapping by combining multiple assay versions, achieving high true positive detection with minimal assays.

A reference map of the human protein interactome

The paper presents HuRI, a comprehensive human protein-protein interaction map, and demonstrates its utility in understanding cellular function and disease mechanisms.