Author

Jose Malagon-Lopez

Harvard University

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Molecular Biology· 1

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Alba CarrerasiD· 1 shared Frank SeeligeriD· 1 shared J. Keith JoungiD· 1 shared Jimmy A. GuoiD· 1 shared Kendell ClementiD· 1 shared Lorenz M. Mayr· 1 shared Luca PinelloiD· 1 shared Maggie L. Bobbin· 1 shared

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2018-2018 · peak 1/yr

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1 shared paperMolecular Biology

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1 paper

Recent·Most cited

In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations

Pınar Akçakaya, Maggie L. Bobbin, Jimmy A. Guo, Jose Malagon-Lopez, Kendell Clement, Sara P. Garcia, Mick D. Fellows, Michelle J. Porritt, Mike A. Firth, Alba Carreras, Tania Baccega, Frank Seeliger, Mikael Bjursell, Shengdar Q. Tsai, Nathalie T. Nguyen, , J. Keith Joung

The paper introduces VIVO, a method to detect off-target mutations from in vivo CRISPR-Cas editing, showing that well-designed gRNAs can edit efficiently without detectable off-targets.

Nature · Sep 1, 2018Peer-reviewedMolecular Biology