Author

Lorenz M. Mayr

AstraZeneca (Sweden)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:variant calling· 2 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Frank SeeligeriD· 2 shared Marcello MarescaiD· 2 shared Michelle J. PorrittiD· 2 shared Mohammad Bohlooly‐YiD· 2 shared Roberto NitschiD· 2 shared Abdel Wahad Bidar· 1 shared Adil MardinoğluiD· 1 shared Alba CarrerasiD· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersGenomics

Frank SeeligerORCID

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Author profile →

3 papers

Recent·Most cited

ObLiGaRe doxycycline Inducible (ODIn) Cas9 system driving pre-clinical drug discovery, from design to cancer treatment

Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Emma Jane Davies, Elizabeth L. Hardaker, Carla P. Martins, Therése Admyre, Amir Taheri‐Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaei-Mahabadi, , Marcello Maresca

This paper introduces an inducible CRISPR-Cas9 system for preclinical drug discovery, enabling controlled genome editing in mice to model cancer and test therapies.

bioRxiv · Apr 6, 2020 · PreprintGenomics

The human secretome - the proteins secreted from human cells

Mathias Uhlén, Hanna Tegel, Åsa Sivertsson, Chih‐Chung Kuo, Jahir M. Gutierrez, Nathan E. Lewis, Björn Forsström, Melanie Dannemeyer, Linn Fagerberg, Magdalena Malm, Helian Vunk, Fredrik Edfors, Andreas Hober, Evelina Sjöstedt, David Kotol, , Sophia Hober

The paper maps and characterizes the human secretome by annotating 2,623 predicted secreted proteins and their spatial distribution, using a high-throughput cell factory for recombinant protein production and analysis.

bioRxiv · Nov 27, 2018 · PreprintMolecular Biology

In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations

Pınar Akçakaya, Maggie L. Bobbin, Jimmy A. Guo, Jose Malagon-Lopez, Kendell Clement, Sara P. Garcia, Mick D. Fellows, Michelle J. Porritt, Mike A. Firth, Alba Carreras, Tania Baccega, Frank Seeliger, Mikael Bjursell, Shengdar Q. Tsai, Nathalie T. Nguyen, , J. Keith Joung

The paper introduces VIVO, a method to detect off-target mutations from in vivo CRISPR-Cas editing, showing that well-designed gRNAs can edit efficiently without detectable off-targets.

Nature · Sep 1, 2018Peer-reviewedMolecular Biology