Author

Maggie L. Bobbin

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:non-human primate· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Aaron DeLoughery· 1 shared Alba CarrerasiD· 1 shared Alexander Neckelmann· 1 shared Alyssa Sancio· 1 shared Benjamin J. RauchiD· 1 shared Bohong ZhangiD· 1 shared Christopher Schmitt· 1 shared Clarissa ScholesiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioengineering

Aaron DeLoughery

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2 papers

Recent·Most cited

Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease

Benjamin J. Rauch, Aaron DeLoughery, Renan B. Sper, Sean Chen, Sophia Yunanda, Megan Masnaghetti, Ning Chai, Jason Ching‐Yao Lin, Alexander Neckelmann, Ymer M. Bjornson, David Páez-Espino, Alyssa Sancio, Christopher Schmitt, Clarissa Scholes, Ria Shah, , Lucas B. Harrington

This paper develops NanoCas, a compact CRISPR nuclease, and demonstrates its efficacy in editing non-liver tissues in non-human primates.

bioRxiv · Jan 29, 2025 · PreprintBioengineering

In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations

Pınar Akçakaya, Maggie L. Bobbin, Jimmy A. Guo, Jose Malagon-Lopez, Kendell Clement, Sara P. Garcia, Mick D. Fellows, Michelle J. Porritt, Mike A. Firth, Alba Carreras, Tania Baccega, Frank Seeliger, Mikael Bjursell, Shengdar Q. Tsai, Nathalie T. Nguyen, , J. Keith Joung

The paper introduces VIVO, a method to detect off-target mutations from in vivo CRISPR-Cas editing, showing that well-designed gRNAs can edit efficiently without detectable off-targets.

Nature · Sep 1, 2018Peer-reviewedMolecular Biology