Alanine Catabolism as a Targetable Vulnerability for MYC-Driven Liver Cancer
Tonatiuh Montoya, Joyce V. Lee, Longhui Qiu, Abigail Krall, Nedas Matulionis, Yurim Seo, Brian N. Finck, Robin K. Kelley, Heather Christofk, Andrei Goga
This study identifies GPT2-dependent alanine catabolism as a metabolic vulnerability in MYC-driven liver cancer, showing that inhibiting GPT2 reduces tumor growth in mouse models.
Cell Reports · Mar 17, 2026Peer-reviewedCancer Biology