Author

Rafaella T. Shima

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Alice E. KaneiD· 1 shared Amber L. MuelleriD· 1 shared Andrei GogaiD· 1 shared Carolyn S. CalfeeiD· 1 shared Charlotte Duesing· 1 shared Christian DieneriD· 1 shared Christopher A. PettyiD· 1 shared Dantong ZhuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

Alice E. KaneORCID

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2 papers

Recent·Most cited

Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury

Vaibhav Upadhyay, Edwin Frank Ortega, Luis A. Ramirez Hernandez, Margaret Alexander, Gagandeep Kaur, Kai R. Trepka, Rachel R. Rock, Rafaella T. Shima, W. Colby Cheshire, Narges Alipanah, Carolyn S. Calfee, Michael A. Matthay, Joyce V. Lee, Andrei Goga, Isha H. Jain, Peter James Turnbaugh

This study shows gut bacteria produce lactate that increases lung epithelial mitochondrial activity and worsens acute lung injury.

bioRxiv · Mar 24, 2025 · PreprintMolecular Biology

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

Alice E. Kane, Karthikeyani Chellappa, Michael B Schultz, Matthew W. Arnold, Jien Li, Joao Amorim, Christian Diener, Dantong Zhu, Sarah Jayne Mitchell, Patrick T. Griffin, Xiao Tian, Christopher A. Petty, Ryan J. Conway, Katie Walsh, Lukas M. Shelerud, , David A. Sinclair

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

bioRxiv · Jun 21, 2024 · PreprintPharmacology & Toxicology