Proteolytic Control of an Auto-inhibitory Intrinsically Disordered Region Governs Small RNA Selectivity in Argonaute Proteins
Ida J. Isolehto, Lizaveta Pshanichnaya, Diego Javier Páez-Moscoso, M. Mager, Ann‐Sophie Seistrup, Jan Schreier, Svenja Hellmann, Kumar Gaurav, Fridolin Kielisch, Juaxuan Chen, Lukas S. Stelzl, René F. Ketting
The paper identifies a novel regulatory mechanism involving proteolytic processing of N-terminal intrinsically disordered regions in C. elegans Argonaute proteins, which controls small RNA selectivity and activity.
bioRxiv · Dec 21, 2025 · PreprintMolecular Biology