Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion
Nikolas Klink, Sebastian Urban, Johanna A. Seier, Bikash Adhikari, Martin P. Schwalm, Juliane Müller, Madeleine Dorsch, Philine Steinbach, Jiwon Jung, Markus Vogt, Farnusch Kaschani, J Koch, Siska Führer, Markus Kaiser, Nina Schulze, , Malte Gersch
This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.
Nature Communications · May 13, 2026Peer-reviewedBiochemistry