Author

Julie A. Losman

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander C.-Y. Tsai· 1 shared Christian GegeiD· 1 shared Daniel P. CahilliD· 1 shared Daniel VittiD· 1 shared Diana D. ShiiD· 1 shared Dorothy M. Junginger· 1 shared Duane Nash· 1 shared Eleanor G. Kaplan· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alexander C.-Y. Tsai

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1 paper

Recent·Most cited

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity

Alexander C.-Y. Tsai, Mathew D. Lin, Vineshkumar Thidil Puliyappadamba, Dorothy M. Junginger, Victoria G. Donovan, Eleanor G. Kaplan, Laura M. Drepanos, Hiroaki Wakimoto, Daniel P. Cahill, Julie A. Losman, Kent William Mouw, Kalil G. Abdullah, John G. Doench, Duane Nash, Daniel Vitt, , Diana D. Shi

This study identifies KDM6 enzymes as targets of R2HG from mutant IDH, linking them to replication stress sensitivity in gliomas and introduces a DHODH inhibitor, GLIO-1, with potential clinical applications.

bioRxiv · Apr 17, 2026 · PreprintCancer Biology