Metabolic plasticity enables cancer adaptation to acidic tumor ecosystems
Raafat Chalar, Naheel Khatri, Jowana Obeid, Joon-Hyun Song, Yujie Xiao, Saiful Samad, A Chen, Andrew E Resnick, K H Karbalaei, Janet J. Allopenna, Cungui Mao, Christopher J. Clarke, Fabiola Noelia Velazquez, Bo Chen, Daniel Canals, , Mehdi Damaghi
This study shows cancer cells adapt to acidic tumor environments through sphingolipid metabolic plasticity, revealing that targeting metabolic flexibility, not individual pathways, may be more effective.
bioRxiv · May 5, 2026 · PreprintCancer Biology