Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes
H. R. Waterman, M. J. Dufort, S. E. Posso, M. Ni, L. Z. Li, C. Zhu, P. Raj, K. D. Smith, J. H. Buckner, J. A. Hamerman
The paper shows IgA1 autoantibodies enhance pDC IFN responses when combined with IgG in RNA-containing immune complexes through FcR receptor interaction.
bioRxiv · Sep 7, 2023Immunology