K. Fan

Simultaneous Identification of Changepoints and Model Parameters in Switching Dynamical Systems

This paper introduces a method to simultaneously estimate changepoints and model parameters in switching dynamical systems, demonstrating its effectiveness through simulations and a real-world COVID-19 case study.

The ecological relevance of flagellar motility in soil bacterial communities

This study investigates the ecological relevance of flagellar motility in soil bacteria by analyzing genomic and metagenomic data across multiple soil environments.

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variant

The paper characterizes structural and functional changes in the SARS-CoV-2 Omicron variant's Spike protein, identifying new immune escape sites and providing insights for vaccine development.

A subset of Memory B-derived antibody repertoire from 3-dose vaccinees is ultrapotent against diverse and highly transmissible SARS-CoV-2 variants, including Omicron

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.

Assessing extraction methods and diversity of anthocyanins from purple-fleshed sweet potatoes grown in cooler climates

This study evaluates anthocyanin extraction methods and diversity in purple-fleshed sweet potatoes grown in cooler climates, finding acidified ethanol extraction as optimal and identifying multiple anthocyanin types.

Highly expressed miR-375 is not an intracellular oncogene in Merkel cell polyomavirus-associated Merkel cell carcinoma

The paper knocks down miR-375 in MCC cell lines and finds no significant changes in viability, morphology, or oncogenic pathways, suggesting miR-375 is not an intracellular oncogene in MCC.

Inhibition of IL-1beta secretion and mitochondria respiration by arsenite which acts on myocardial ischemia-reperfusion injury

The paper investigates arsenite's effects on IL-1beta secretion, mitochondrial respiration, and myocardial ischemia-reperfusion injury in rats.

Endoplasmic reticulum associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

This study shows that ERAD preserves HSC quiescence and self-renewal by restricting mTOR activity, preventing HSC depletion and hyper-proliferation.

OxyR senses reactive sulfane sulfur and activates genes for its removal in Escherichia coli

The paper shows OxyR in E. coli detects reactive sulfane sulfur and activates genes for its removal via thioredoxin and glutaredoxin.

Depression and Anxiety in Healthcare Staffs in A Tertiary University Hospital in Luoyang, Henan Province: A Cross-Sectional Observational Study

This study assesses depression and anxiety prevalence among healthcare staff in a Chinese hospital, identifying workplace violence and poor sleep as key risk factors.

Optimization of accelerated solvent extraction of fatty acids from Coix seeds using chemometrics methods

This study optimizes fatty acid extraction from Coix seeds using chemometrics methods, finding that different extraction conditions are optimal for each seed type.

Near-Atomic Resolution Structure Determination in Over-Focus with Volta Phase Plate by Cs-corrected Cryo-EM

The paper demonstrates the use of Volta phase plate with Cs-corrected TEM to achieve near-atomic resolution structures of apo-ferritin from over-focused images.