K. Flisikowski

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer

The paper shows that secondary bile acids from gut bacteria worsen colorectal cancer in a Western diet model.

A translational swine model for Crohn`s disease

This paper develops a genome-edited swine model of Crohn's disease that replicates key human disease features to enable translational research.

Porcine model elucidates function of p53 isoform in carcinogenesis

This study uses a porcine model to show that specific p53 isoforms and circular TP53 RNA drive tumorigenesis, particularly osteosarcoma, in pigs and likely have similar roles in humans.